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's father died antiviral chemotherapy. Luc Montagnier-

The New York Times Skidding few days ago the death of William H. Prusoff, a leading pharmacologist at Yale and "father of antiviral chemotherapy."

Dr. Prusoff developed in the 50 antivirales.El drugs first was idoxuridine, which Prusoff synthesized for the first time in 1959.Esta cytotoxic molecule similar to those used by the virus, it works through a biochemical phenomenon called antimetabolites, and serves to destabilize the viral replication within cells.

Since then Dr. Prusoff spent much of his long career studying molecular derivatives impiesen the extent of DNA chain and decrease viral replication, until the mid 1980's, it was the jackpot:

With the spread of the AIDS epidemic, Dr. Prusoff and a colleague at Yale, Tai-shun Lin began to familiar with analogue reverse transcriptase inhibitors Conversely, as stavudine (d4T), very similar to AZT, which was the first drug for AIDS. Both originally developed in 1964 by Dr. Jerome Horowitz of the Michigan Cancer Foundation and used in evidence against cancer but later abandoned as ineffective and toxic.



The Stavudine approved by the FDA in 1992, began to be sold in pill form in 1994 under the brand Zerit.Fármaco realacionado molecularly closely with other nucleoside analogues belonging to the same family as zidovudine (AZT) , didanosine (ddI) and Zalcitabine (ddC).
For a long time was the drug Stavudine most used for AIDS. Has generated revenue of tens of millions of dollars to Yale, many more than the rest of pantentes in conjunction with that has been used.

Dr. Prusoff, also was a member of a campaign by Doctors Without Borders to persuade Bristol-Meyers to reduce the price of the drug in Africa. However

the World Health Organization (WHO) advised withdrawal in 2009 . Because this drug causes nervous disorders, particularly chronic weakness, numbness, body numbness, burning pain in hands and feet, loss of lean body mass, legs, arms or any other body part ...

Actalmente the Stavudine is used mainly in poor countries, because it is a cheap product that continues to be accessible.

many people will have to keep dying due to the toxicity of these drugs or cancer chemotherapy?